Law enforcement officers are present outside the home of Nancy Guthrie, the mother of "Today" host Savannah Guthrie, near Tucson, Ariz., Monday, Feb. 2, 2026. (AP Photo/Sejal Govindarao)

(AP) — There has been no response to an emotional plea from “Today” show host Savannah Guthrie to her mother’s apparent kidnapper, authorities said Thursday, and investigators have no evidence Nancy Guthrie is still alive after being taken from her home in Tucson, Arizona, over the weekend.

The search has grown increasingly urgent because the 84-year-old grandmother has a pacemaker, heart issues and could die without her medication, Pima County Sheriff Chris Nanos has said. But at a press conference Thursday, law enforcement said there still weren’t any notable suspects. A DNA test of blood found on the home’s front porch showed it came from Nancy Guthrie, the sheriff said.

A handful of media organizations were reportedly sent ransom notes related to her disappearance, and at least one appears to contain information only the abductor would know, the outlet reported.

Here’s what to know about the case:

Message to kidnappers

In a video posted Wednesday night, Savannah Guthrie sat between her sister Annie and her brother Camron as she read a prepared statement, her voice shaking.

“We are ready to talk. However, we live in a world where voices and images are easily manipulated,” she said, adding. “We need to know without a doubt that she is alive and that you have her. We want to hear from you and we are ready to listen. Please reach out to us.”

Law enforcement said there hasn’t been a credible response to the family’s video.

“The family wants to be contacted. They know time is of the essence,” said Heith Janke, FBI chief in Phoenix. He also announced a $50,000 reward for credible information about the abduction.

Ransom notes taken ‘seriously’

A note emailed Monday to the KOLD-TV newsroom in Tucson included information only the kidnapper could have, anchor Mary Coleman told CNN.

“When we saw some of those details, it was clear after a couple of sentences that this might not be a hoax,” she said in an interview aired Wednesday.

The note included a demand for money with a deadline set for 5 p.m. Thursday and a second one Monday.

Authorities made an arrest after a ransom note turned out to be fake, but the others are being investigated. Ultimately, the Guthrie family will decide how to respond to the demands, law enforcement said.

Crime scene in a quiet neighborhood

Investigators say Nancy Guthrie was dropped off at home by a family member on Saturday evening. Four hours later, just before 2 a.m. Sunday, the home’s doorbell camera was disconnected. But she did not have an active subscription so the company was unable to recover any video.

Software data recorded movement at the home a few minutes later, the sheriff said, acknowledging that the motion could have come from an animal.

Then at 2:28 a.m. the app on Guthrie’s pacemaker was disconnected from her phone. She was reported missing around noon Sunday when she didn’t show up to church.

Several personal items, including Guthrie’s cellphone, wallet and car, were still at the home when authorities searched it, according to a person familiar with the investigation.

Nancy Guthrie lived alone in the upscale Catalina Foothills neighborhood, where houses are spaced far apart and set back from the street by long driveways, gates and dense desert vegetation. The area appears to have little street lighting at night, making it less likely that security cameras captured helpful footage.

But no clear motive

Investigators don’t know whether Nancy Guthrie was targeted because her daughter is one of television’s most visible anchors, the sheriff said.

When asked by The Associated Press whether law enforcement knew the reason why, Nanos responded, “My guesswork is as good as yours.”

Strong mother figure

Savannah Guthrie, the youngest of three siblings, grew up in Tucson, graduated from the University of Arizona and previously worked as a reporter and anchor at KVOA-TV before joining “Today” in 2011.

In Wednesday’s video, she described her mother as a “kind, faithful, loyal, fiercely loving woman of goodness and light.”

Savannah’s sister Annie added: “Mamma, If you’re listening, we need you to come home. We miss you.”